Phase I

Nav1.7 Blockers- New Genre of Pain Relief Therapy

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Voltage-gated sodium channels are membrane proteins, a polypeptide chain of more than 1800 amino acids that conduct sodium ions at high rates. They are embedded in the plasma membrane and are actively present in the nerve and muscle cells used in the rapid electrical signaling. Nav channels are therapeutic targets for many cardiovascular and neurological disorders. The different subtypes of voltage gated sodium channel include Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.5, Nav1.6, Nav1.7, Nav1.8 and Nav1.9 channels.

Nav1.7 is involved in early phases of neuronal electrogenesis. Mutations in Nav1.7 channel can caused Familial Rectal Pain (FRP) and Paroxysmal Extreme Pain Disorder (PEPD) in humans. Studies by James Cox and Geoff Woods et al. have demonstrated that Nav1.7 leads to pain signaling and generation in humans. Mutation in T2573A and T2543C in Nav1.7 can cause primary erythermalgia. Nav1.7 acts as a promising target in the pain perception pathway. Blockers of Nav1.7 channels have great potential as analgesics, and therapy for the treatment of chronic pain including dental pain, pain associated with osteoarthritis, erythromelalgia, diabetic neuropathy, peroxymal extreme pain disorder (PEPD), neuropathic pain and ocular pain. Benzazepinone, amino-thiazoles, amino-pyridines and isoxazoles are inhibitors of Nav1.7 that provide the desired treatment for pain with fewer side effects. ProTx-II isolated from tarantula Thrixopelma prurient is blocker of Nav1.7 channels. Peptides that are present in venoms of snakes and spiders are also the source ion channel blockers.

Currently, there are some major companies that involved in Nav 1.7 blocker drugs development including Amgen, Biogen, Genentech, Teva Pharmaceuticals, and Sumitomo Dainippon. These companies are in initial phase of development with drugs either in Preclinical stage of development or in Phase I stage.

These Nav 1.7 blockers are on the hit list of companies and it’s quite evident with active alliances and acquisitions that they are working with great hopes towards it. The joint venture of Purdue Pharma and AnaBios Corporation in the year 2015 is a sign that researchers have found this compound to be of great commercial value and hence companies are moving ahead in the domain of chronic pain treatment using AnaBios’ Phase-X technology. Not only this, in January 2016 Biogen acquired Convergence Pharmaceuticals that brings along Convergence’s Phase 2 chronic pain compound CNV1014802 to Biogen, thereby expanding their chronic pain portfolio.

Nav1.7 blockers have an edge over other conventional blockers as they are more targets specific and can also be used to deliver non-selective local anesthetic. Nav1.7 blockers prevent motor side effects that occur due to other pain relief therapies. Preclinical studies that are ongoing have shown satisfactory results till now with very few cases of adverse effects and in future we can assume that Nav1.7 blockers can come up as a new genre of pain relief therapy for future with much broader efficacy range and less adverse effects.

Insight by :
Anurag Mathur
Associate Analyst
DelveInsight Business Research

 

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Anticoagulants (VTE & AF) Therapeutics Market is estimated to reach $17.2 billion by 2020

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The Anticoagulants (VTE & AF) Therapeutics Market was around $11.4 billion in 2015 and is estimated to reach $17.2 billion by 2020 growing at a CAGR of 8.59% from 2015 to 2020.

DelveInsight Report “Anticoagulants-Market Insights & Drugs Sales Forecast (VTE & AF) -2020” provides an overview of the Anticoagulants andAtrial Fibrillation and Venous Thromboembolism. The Report majorlyemphasizes on the global Anticoagulants market size and market size of theAnticoagulants by 7 Major Markets (United States, EU5 (France, Germany,Italy, Spain, UK) and Japan). The Report also covers the market size of Atrial

Fibrillation and Venous thromboembolism along with the market sales of the Key drugs by VTE and AF indications. It provides comprehensive review of Market Drivers, Market Barriers, Anticoagulants with coverage of detailed profile, Cost of therapy, Safety and Efficacy profiles and SWOT analysis.

The global anticoagulants market is categorized based on different classes like vitamin K reductase Inhibitor, heparin, low molecular weight heparin, Factor Xa Inhibitor and thrombin inhibitors.

Global AF market was $7.2 billion in 2015 and is expected to grow to $12.5 billion by 2020 with an compound annual growth rate (CAGR) of 11.62% where as Global VTE market was $4.2 billion in 2015 and is expected to grow to $4.75 billion by 2020 with a compound annual growth rate (CAGR) of 2.44%

With the recommendation of usage of novel oral anticoagulants (NOAC) by International guidelines in line with their established safety, efficacy and compliance, we expect decrease of warfarin use at a CAGR of negative 3.20% from 2015-2020 due to patient preferences in switching from warfarin to NOAC at a significant rate.  Novel Oral Anticoagulants (NOAC) will continue to be first-line oral agents, accounting for 70% of major-market sales in 2015.

Insights from recent studies clearly indicates that Physicians are relatively satisfied with the NOACs due to its efficacy and positive safety profiles without the need for anticoagulation monitoring and
dose frequencies. Conventional therapies (i.e., Warfarin) will remain entrenched as first-line therapies for most of the AF and VTE patients, followed by novel oral anticoagulants (NOAC) in the developing and underdeveloped countries due to the high cost of NOAC medications.

For more information on this report email us at info@delveInsight.com.

DelveInsight is a leading Business Consulting and Market Research Firm. DelveInsight helps the clients to find answers relevant to their business, facilitating decision-making; identify potential market opportunities, competitor assessments and business environmental assessment. In addition to this DelveInsight also deals in providing custom research services in coherence with interest area of the clients.

Our Formula For Mechanism Of Action Is So Effective We’d Patent It If We Could

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DelveInsight’s Mechanism of Action Reports has become the Success Reason for the Leading Pharma Companies

In this competitive world, everybody wants to get aware of what others are doing in their sectors and what strategic drivers are followed by the others for the successful future milestones. But the drug future is only dependent on one thing and that is how much efficacy it is showing through its mechanism of action to improve the medical condition. So utilizing the most effective targets and technology, the drug can do million dollar business.

DelveInsight released Mechanism of Action reports provides the targets-mode of action based information-across all the therapy under research work, pipeline products across all the companies, current technology, molecule type, stage, company finances, comparative analysis and therapeutic assessment at every step. These Reports propose specific strategies that could have the most substantial impact in improving R&D productivity.

“We are really happy that our reports are showing potential in the market. We have become a strategic partner for the Pharma Companies worldwide” said Dr. B.K. Agrawal, Managing Partner at DelveInsight Business Research.

These Reports highlights therapeutic targets and their mode of action; for instance Inflammatory targets: Reversible Anticholinesterases, Sphingosine 1-Phosphate (S1P) Inhibitors, c-jun-N-Terminal Kinase (JNK) inhibitors, Cancer Targets: Gamma Secretase inhibitors, IL-13 Receptor Antagonists and many more…..

DelveInsight’s Mechanism of Action reports is not only gaining importance but also has become the most known among the clients.

These reports are available with many resellers like Report Linkers, Report Buyers, Research moz, ASD Reports, Report Stack, Bharat Book Bureau and Market Reports.

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Infectious Disease and Vaccines Pipeline Reports

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DelveInsight is helping worldwide Pharmaceutical companies with its Market Intelligence Reports.

VISIT OUR WEBSITE

Infectious Diseases and Vaccines

The infectious disease (ID) vaccine pipeline is rich and robust. However, indications such as HIV, Tuberculosis and HCV have high demand for the development of a first vaccine, and even routine vaccinations, such as those for influenza can be improved in terms of safety and efficacy. Such unmet needs are driving the continued development of ID vaccines.

Get  Notified About Whats in Others Pipeline

The research work for curing Infectious disease has rapidly assumed a prioritized role within the overall scientific portfolio. The number of vaccines development underway has increased substantially for the HCV, HIV, Tuberculosis and Influenza infections.

Get notified about all the under development vaccines worldwide and the technology they are using, stage of development, their targets, mechanism of action with our Pipeline reports. The best strategic report that will not even give you the overall developing drug profiles but also therapeutic assessment and comparative analysis at every step such as monotherapy, combination, route of administration.

Pipeline Insights Reports

HCV Vaccine-Pipeline Insights, 2014 

HIV Vaccine-Pipeline Insights, 2014 

Influenza Vaccine-Pipeline Insights, 2014 

Tuberculosis Vaccine-Pipeline Insights, 2014

ASK FOR SAMPLE PAGES NOW

For further information email us at info@delveinsight.com

Ebola Virus Drugs Approved or Still in Pipeline. What’s the mystery?

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Get informed about the Current Drugs in Pipeline with DelveInsight “’Ebola Viral InfectionsPipeline Insights, 2014′, Report

About Virus

Ebola virus disease (formerly known as Ebola haemorrhagic fever) is a severe, often fatal illness, with a case fatality rate of up to 90%. Ebola first appeared in 1976 in 2 simultaneous outbreaks, in Nzara, Sudan, and in Yambuku, Democratic Republic of Congo. The latter was in a village situated near the Ebola River, from which the disease takes its name.

The 2014 Ebola outbreak is one of the largest Ebola outbreaks in history and the first in West Africa. It is affecting four countries in West Africa: Guinea, Liberia, Nigeria, and Sierra Leone.

Disease update

Confirmed, probable, and suspect cases and deaths from Ebola virus disease in Guinea, Liberia, Nigeria, and Sierra Leone, as of 16 August 2014

Total Cases in West Africa

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Cases and Death by Country

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Vaccine and treatment

No licensed vaccine for EVD is available. Several vaccines are being tested, but none are available for clinical use.

Fast Track Drugs in Pipeline

Tekmira

In March 5, 2014, U.S. Food and Drug Administration (FDA) has granted Fast Track designation for the development of TKM-Ebola, an anti-Ebola viral therapeutic of Tekmira Pharmaceuticals Corporation.

The TKM-Ebola drug is being developed by Tekmira and the U.S. Department of Defense’s medical countermeasure systems biodefense therapeutics joint product management office under a $140 million contract.

The anti-Ebola virus RNAi therapeutic has been used in preclinical studies to treat previously infected “non-human primates”, with results showing 100 percent protection from an otherwise lethal dose of Zaire Ebola virus.

In January 2014, Tekmira commenced a Phase I clinical trial using TKM-Ebola. The TKM-Ebola Phase I clinical trial is a randomized, single-blind, placebo-controlled study involving single ascending doses and multiple ascending doses of TKM-Ebola. The study will assess the safety, tolerability and pharmacokinetics of administering TKM-Ebola to healthy adult subjects.

RISK

KM-Ebola may not prove to be an effective anti-viral therapy for hemorrhagic fever viruses; data from the TKM-Ebola Phase I human clinical trial may not be available as currently anticipated, or at all; the U.S. Department of Defense may suspend or terminate its participation in the TKM-Ebola program; the Fast Track designation from the FDA may not result in faster development times or earlier approvals; and Tekmira’s products may not prove to be effective or as potent as currently believed.

AVI-7537

On Sep 18, 2012, U.S. Food and Drug Administration (FDA) has granted Fast Track status for the development of Sarepta Therapeutic’s lead infectious disease drug candidate, AVI-7537, a different type modified RNA molecule. AVI-7537 is directed against one of the three Ebolavirus genes (VP24). The chemistry platform utilized for development is PMOplus. AVI-7537 also works via a different mechanism to block the viral protein from being made.

Sarepta had been conducting Phase 1 safety trials with the drug alone and together another Ebola-directed PMOplus molecule (AVI-7539, with the combination called AVI-6002).

Currently Given Non-Licensed Drug

ZMapp

American missionary Ebola patients, Dr. Kent Brantly and Nancy Writebol are given biotech product, called ZMapp, are indeed still experimental – it’s not yet approved for human use, and not yet even in phase I clinical trials.

The ZMapp three-antibody cocktail isn’t a vaccine. Instead, it provides an artifical immune response against sugar-tagged proteins on the outside of the Ebolavirus.

ZMappTM is composed of three “humanized” monoclonal antibodies manufactured in, specifically Nicotiana. It is an optimized cocktail combining the best components of MB-003 (Mapp) and ZMAb (Defyrus/PHAC). ZMappTM was first identified as a drug candidate in January 2014 and has not yet been evaluated for safety in humans.

WHAT’S IN THE PIPELINE?

There are about a half dozen Ebola drugs and vaccines in development, several of which have received funding from the U.S. 

For more information on Pipeline drugs of Ebola Virus get the DelveInsight’s Report Ebola Viral Infections-Pipeline Insights, 2014′ in just $1250.

For more information contact info@delveinsight.com

Or

Please visit Report BuyerReportLinkerASD MediaMarket Report (Japan)Market Publishers VPG MarketResearch Bharat Book Bureau

Sources:

http://www.fda.gov/ForConsumers/ByAudience/ForPatientAdvocates/SpeedingAccesstoImportantNewTherapies/ucm128291.htm

http://www.tekmira.com/pipeline/tkm-ebola.php

http://www.cdc.gov/vhf/ebola/outbreaks/guinea/

http://freedomoutpost.com/2014/08/west-africans-streaming-across-u-s-southern-border-carrying-ebola-virus/

http://www.who.int/csr/don/2014_08_19_ebola/en/

http://www.mappbio.com/zmapinfo.pdf

https://www.bharatbook.com/healthcare-market-research-reports-511074/ebola-viral-infections-pipeline-insights1.html

http://www.latimes.com/science/sciencenow/la-sci-sn-ebola-serum-20140804-story.html

Metastatic Prostate Cancer-Pipeline Insights, 2014

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DelveInsight’s,“ Metastatic Prostate Cancer-Pipeline Insights, 2014”, report provides comprehensive insights about pipeline drugs across this indication. A key objective of the report is to establish the understanding for all the pipeline drugs that fall under Metastatic Prostate Cancer. This report provides information on the therapeutic development based on the Metastatic Prostate Cancer dealing with all the pipeline drugs, comparative analysis at various stages covering Filed, Phase III, Phase II, Phase I, IND filed, Preclinical, Discovery and unknown stages, therapeutics assessment by monotherapy and combination products and molecule type drug information. The report also covers the companies information involved in the therapeutic development of the products. It also has highlighted the discontinued and dormant products.

Scope
– The report provides a snapshot of the global therapeutic landscape of Metastatic Prostate Cancer
– The report provides pipeline products under drug profile section which includes product description, MOA, licensors & collaborators, development partner and chemical information
– Coverage of the Metastatic Prostate Cancer pipeline on the basis of target, MOA, route of administration, technology involved and molecule type
– The report reviews key players involved in the therapeutics development for Metastatic Prostate Cancer and also provide company profiling
– The report also gives the information of dormant and discontinued pipeline projects
– Pipeline products coverage based on various stages of development ranging from preregistration till discovery and undisclosed stages
– Provides pipeline assessment by monotherapy and combination therapy products, stage of development and molecule type

Reasons to buy
– Complete Pipeline intelligence and complete understanding over therapeutics development for Metastatic Prostate Cancer
– Identify the relationship between the drugs and use it for target finding, drug repurposing, and precision medicine.
– Devise corrective measures for pipeline projects by understanding Metastatic Prostate Cancer pipeline depth and focus of Indication therapeutics
– Developing strategic initiatives to support your drug development activities.
– Optimize your portfolio and keep you in touch with the rapidly changing pharmaceutical markets, and make the best decisions for your business.
– Develop and design in licensing and out licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope
– Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies
– Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline
– Gaining a Full Picture of the Competitive Landscape for Evidence based Decisions

Table of Contents
– Metastatic Prostate Cancer Overview
– Metastatic Prostate Cancer Pipeline Therapeutics
– Metastatic Prostate Cancer Therapeutics under Development by Companies
– Metastatic Prostate Cancer Late Stage Products (Filed and Phase III)
– Comparative Analysis
– Metastatic Prostate Cancer Mid Clinical Stage Products (Phase II)
– Comparative Analysis
– Metastatic Prostate Cancer Early Clinical Stage Products (Phase I and IND Filed)
– Comparative Analysis
– Metastatic Prostate Cancer Discovery and Pre-Clinical Stage Products
– Comparative Analysis
– Drug Candidate Profiles
– Metastatic Prostate Cancer – Therapeutics Assessment
– Assessment by Monotherapy Products
– Assessment by Combination Products
– Assessment by Route of Administration
– Assessment by Molecule Type
– Metastatic Prostate Cancer – Discontinued Products
– Metastatic Prostate Cancer – Dormant Products
– Companies Involved in Therapeutics Development for Metastatic Prostate Cancer
– Appendix
– Methodology
– Contact Us
– Disclaimer

List of Tables

– Number of Products under Development for Metastatic Prostate Cancer, 2014
– Number of Products under Development by Companies
– Comparative Analysis by Late Clinical Stage Products (Filed and Phase III), 2014
– Comparative Analysis Mid Clinical Stage Products (Phase II), 2014
– Comparative Analysis Early Clinical Stage Products (Phase I and IND Filed), 2014
– Comparative Analysis Discovery and Pre-Clinical Stage Products, 2014
– Drug Candidates Profiles
– Metastatic Prostate Cancer Assessment by Monotherapy Products
– Metastatic Prostate Cancer Assessment by Combination Products
– Metastatic Prostate Cancer Assessment by Route of Administration
– Metastatic Prostate Cancer Assessment by Stage and Route of Administration
– Metastatic Prostate Cancer Assessment by Molecule Type
– Metastatic Prostate Cancer Assessment by Stage and Molecule Type
– Metastatic Prostate Cancer Therapeutics – Discontinued Products
– Metastatic Prostate Cancer Therapeutics – Dormant Products
– Products under Development by Companies, 2014

List of Figures

– Number of Products under Development for Metastatic Prostate Cancer, 2014
– Late Clinical Stage Products (Filed and Phase III), 2014
– Mid Clinical Stage Products (Phase II), 2014
– Early Clinical Stage Products (Phase I and IND Filed), 2014
– Discovery and Pre-Clinical Stage Products, 2014
– Metastatic Prostate Cancer Assessment by Monotherapy Products
– Metastatic Prostate Cancer Assessment by Combination Products
– Metastatic Prostate Cancer Assessment by Route of Administration
– Metastatic Prostate Cancer Assessment by Stage and Route of Administration
– Metastatic Prostate Cancer Assessment by Molecule Type
– Metastatic Prostate Cancer Assessment by Stage and Molecule Type

Report Pricing
Single User License: $1250
Site License:$2500
Global License:$4000

For Sample Pages and Report, please contact us at info@delveinsight.com

Brain Hemorrhage-Pipeline Insights, 2014

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DelveInsight’s, Brain Hemorrhage-Pipeline Insights, 2014”, report provides comprehensive insights about pipeline drugs across this indication. A key objective of the report is to establish the understanding for all the pipeline drugs that fall under Brain Hemorrhage. This report provides information on the therapeutic development based on the Brain Hemorrhage dealing with all the pipeline drugs, comparative analysis at various stages covering Filed, Phase III, Phase II, Phase I, IND filed, Preclinical, Discovery and unknown stages, therapeutics assessment by monotherapy and combination products and molecule type drug information. The report also covers the companies information involved in the therapeutic development of the products. It also has highlighted the discontinued and dormant products.

Scope
– The report provides a snapshot of the global therapeutic landscape of Brain Hemorrhage
– The report provides pipeline products under drug profile section which includes product description, MOA, licensors & collaborators, development partner and chemical information
– Coverage of the Brain Hemorrhage pipeline on the basis of target, MOA, route of administration, technology involved and molecule type
– The report reviews key players involved in the therapeutics development for Brain Hemorrhage and also provide company profiling
– The report also gives the information of dormant and discontinued pipeline projects
– Pipeline products coverage based on various stages of development ranging from preregistration till discovery and undisclosed stages
– Provides pipeline assessment by monotherapy and combination therapy products, stage of development and molecule type

Reasons to buy
– Complete Pipeline intelligence and complete understanding over therapeutics development for Brain Hemorrhage
– Identify the relationship between the drugs and use it for target finding, drug repurposing, and precision medicine.
– Devise corrective measures for pipeline projects by understanding Brain Hemorrhage pipeline depth and focus of Indication therapeutics
– Developing strategic initiatives to support your drug development activities.
– Optimize your portfolio and keep you in touch with the rapidly changing pharmaceutical markets, and make the best decisions for your business.
– Develop and design in licensing and out licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope
– Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies
– Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline
– Gaining a Full Picture of the Competitive Landscape for Evidence based Decisions

Table of Contents

– Brain Hemorrhage Overview
– Brain Hemorrhage Pipeline Therapeutics
– Brain Hemorrhage Therapeutics under Development by Companies
– Brain Hemorrhage Late Stage Products (Filed and Phase III)
– Comparative Analysis
– Brain Hemorrhage Mid Clinical Stage Products (Phase II)
– Comparative Analysis
– Brain Hemorrhage Early Clinical Stage Products (Phase I and IND Filed)
– Comparative Analysis
– Brain Hemorrhage Discovery and Pre-Clinical Stage Products
– Comparative Analysis
– Drug Candidate Profiles
– Brain Hemorrhage – Therapeutics Assessment
– Assessment by Monotherapy Products
– Assessment by Combination Products
– Assessment by Route of Administration
– Assessment by Molecule Type
– Brain Hemorrhage – Discontinued Products
– Brain Hemorrhage – Dormant Products
– Companies Involved in Therapeutics Development for Brain Hemorrhage
– Appendix
– Methodology
– Contact Us
– Disclaimer

List of Tables

– Number of Products under Development for Brain Hemorrhage, 2014
– Number of Products under Development by Companies
– Comparative Analysis by Late Clinical Stage Products (Filed and Phase III), 2014
– Comparative Analysis Mid Clinical Stage Products (Phase II), 2014
– Comparative Analysis Early Clinical Stage Products (Phase I and IND Filed), 2014
– Comparative Analysis Discovery and Pre-Clinical Stage Products, 2014
– Drug Candidates Profiles
– Brain Hemorrhage Assessment by Monotherapy Products
– Brain Hemorrhage Assessment by Combination Products
– Brain Hemorrhage Assessment by Route of Administration
– Brain Hemorrhage Assessment by Stage and Route of Administration
– Brain Hemorrhage Assessment by Molecule Type
– Brain Hemorrhage Assessment by Stage and Molecule Type
– Brain Hemorrhage Therapeutics – Discontinued Products
– Brain Hemorrhage Therapeutics – Dormant Products
– Products under Development by Companies, 2014

List of Figures

– Number of Products under Development for Brain Hemorrhage, 2014
– Late Clinical Stage Products (Filed and Phase III), 2014
– Mid Clinical Stage Products (Phase II), 2014
– Early Clinical Stage Products (Phase I and IND Filed), 2014
– Discovery and Pre-Clinical Stage Products, 2014
– Brain Hemorrhage Assessment by Monotherapy Products
– Brain Hemorrhage Assessment by Combination Products
– Brain Hemorrhage Assessment by Route of Administration
– Brain Hemorrhage Assessment by Stage and Route of Administration
– Brain Hemorrhage Assessment by Molecule Type
– Brain Hemorrhage Assessment by Stage and Molecule Type

Report Pricing

Single User: USD 1250
Site License: USD 2500
Global License: USD 4000

To order the Sample Pages and the Report please contact below:

Email: info@delveinsight.com

Source: DelveInsight