Pharma Companies

Antibody Drug Conjugate and Big Pharmaceutical Companies

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Antibody Drug Conjugate and Big Pharmaceutical Companies Boom

Antibody-drug conjugates is gaining popularity in the Biopharmaceutical industries. As Initial trials with these targeted treatments show success, more companies are looking to produce these drugs. Although antibody-drug conjugates show promise in the development of effective cancer therapies, there are still a variety of challenges involved in enabling the safe manufacture of these hazardous drugs. ADC’s continues to gain popularity but the market is in infant stage with only 3 drugs approved by U.S. FDA.

  1. Mylotarg from Wyeth (now Pfizer) was the 1st drug approved for the treatment of acute myeloid leukaemia back in 2000 but was withdrawn a decade later.
  2. Adcetris (brentuximab vedotin) from Seattle Genetics was approved by the FDA in 2011 for the treatment of Hodgkin’s lymphoma and systemic anaplastic large cell lymphoma.
  3. Genentech’s Kadcyla (ado-trastuzumab emtansine) was given FDA approval in early 2013. ImmunoGen holds patents on Kadcyla and how it is manufactured, and receive royalties from Roche on its sales.

More than 264 Antibody-drug conjugates are under pipeline and as the large numbers of pharmaceutical companies are involved in antibody-drug conjugates market, therefore it is expected that this market will grow rapidly.

DALJDljADLAlthough the market now has presence of many large pharmaceutical companies, but the technology lies with only few. Seattle Genetics and ImmunoGen are the pioneers in technology licensing, with most drugs using their technology.

The future of ADCs in the biopharmaceutical market will ultimately depend on their clinical success. Companies and researchers are seeking to meet that challenge by optimizing the selection of all the components in the ADC—the antibody, linker, and cytotoxin—and successfully combining manufacturing techniques for both high- potency APIs and biologics. Earlier unsuccessful attempts to generate ADCs with therapeutic value have emphasized the important role each component plays in determining the efficacy and safety of the final ADC.

Since ADC’s are highly complex to manufacture, it provides unique opportunities and challenges to Contract Manufacturers Organizations (CMOs) and biopharmaceutical companies seeking CMP partners for their ADC candidates.

In some cases, three separate CMOs are utilized- one for the chemical linker, one for the antibody and one for the highly potent drug. Then, everything is shipped to someone else for conjugation.

Some CMO’s which offer ADC Conjugation services include: Lonza, Laureate Biopharma, Piramal Healthcare Pharma Solutions, Abbott contracts manufacturing, Aquitaine Pharm International, etc.

ADCs are sometimes described as armed antibodies, and their cytotoxic components as warheads. Whether ADCs will prove to be an effective weapon against cancer or other diseases has yet to be seen as more are tested in the clinic.

By Shriya Sahni, Associate Analyst, DelveInsight

For more information on this Report, please mail at info@delveInsight.com

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Our Formula For Mechanism Of Action Is So Effective We’d Patent It If We Could

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DelveInsight’s Mechanism of Action Reports has become the Success Reason for the Leading Pharma Companies

In this competitive world, everybody wants to get aware of what others are doing in their sectors and what strategic drivers are followed by the others for the successful future milestones. But the drug future is only dependent on one thing and that is how much efficacy it is showing through its mechanism of action to improve the medical condition. So utilizing the most effective targets and technology, the drug can do million dollar business.

DelveInsight released Mechanism of Action reports provides the targets-mode of action based information-across all the therapy under research work, pipeline products across all the companies, current technology, molecule type, stage, company finances, comparative analysis and therapeutic assessment at every step. These Reports propose specific strategies that could have the most substantial impact in improving R&D productivity.

“We are really happy that our reports are showing potential in the market. We have become a strategic partner for the Pharma Companies worldwide” said Dr. B.K. Agrawal, Managing Partner at DelveInsight Business Research.

These Reports highlights therapeutic targets and their mode of action; for instance Inflammatory targets: Reversible Anticholinesterases, Sphingosine 1-Phosphate (S1P) Inhibitors, c-jun-N-Terminal Kinase (JNK) inhibitors, Cancer Targets: Gamma Secretase inhibitors, IL-13 Receptor Antagonists and many more…..

DelveInsight’s Mechanism of Action reports is not only gaining importance but also has become the most known among the clients.

These reports are available with many resellers like Report Linkers, Report Buyers, Research moz, ASD Reports, Report Stack, Bharat Book Bureau and Market Reports.

Ask for sample reports now!

For more information please contact info@delveinsight.com

Infectious Disease and Vaccines Pipeline Reports

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DelveInsight is helping worldwide Pharmaceutical companies with its Market Intelligence Reports.

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Infectious Diseases and Vaccines

The infectious disease (ID) vaccine pipeline is rich and robust. However, indications such as HIV, Tuberculosis and HCV have high demand for the development of a first vaccine, and even routine vaccinations, such as those for influenza can be improved in terms of safety and efficacy. Such unmet needs are driving the continued development of ID vaccines.

Get  Notified About Whats in Others Pipeline

The research work for curing Infectious disease has rapidly assumed a prioritized role within the overall scientific portfolio. The number of vaccines development underway has increased substantially for the HCV, HIV, Tuberculosis and Influenza infections.

Get notified about all the under development vaccines worldwide and the technology they are using, stage of development, their targets, mechanism of action with our Pipeline reports. The best strategic report that will not even give you the overall developing drug profiles but also therapeutic assessment and comparative analysis at every step such as monotherapy, combination, route of administration.

Pipeline Insights Reports

HCV Vaccine-Pipeline Insights, 2014 

HIV Vaccine-Pipeline Insights, 2014 

Influenza Vaccine-Pipeline Insights, 2014 

Tuberculosis Vaccine-Pipeline Insights, 2014

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For further information email us at info@delveinsight.com

Metastatic Prostate Cancer-Pipeline Insights, 2014

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DelveInsight’s,“ Metastatic Prostate Cancer-Pipeline Insights, 2014”, report provides comprehensive insights about pipeline drugs across this indication. A key objective of the report is to establish the understanding for all the pipeline drugs that fall under Metastatic Prostate Cancer. This report provides information on the therapeutic development based on the Metastatic Prostate Cancer dealing with all the pipeline drugs, comparative analysis at various stages covering Filed, Phase III, Phase II, Phase I, IND filed, Preclinical, Discovery and unknown stages, therapeutics assessment by monotherapy and combination products and molecule type drug information. The report also covers the companies information involved in the therapeutic development of the products. It also has highlighted the discontinued and dormant products.

Scope
– The report provides a snapshot of the global therapeutic landscape of Metastatic Prostate Cancer
– The report provides pipeline products under drug profile section which includes product description, MOA, licensors & collaborators, development partner and chemical information
– Coverage of the Metastatic Prostate Cancer pipeline on the basis of target, MOA, route of administration, technology involved and molecule type
– The report reviews key players involved in the therapeutics development for Metastatic Prostate Cancer and also provide company profiling
– The report also gives the information of dormant and discontinued pipeline projects
– Pipeline products coverage based on various stages of development ranging from preregistration till discovery and undisclosed stages
– Provides pipeline assessment by monotherapy and combination therapy products, stage of development and molecule type

Reasons to buy
– Complete Pipeline intelligence and complete understanding over therapeutics development for Metastatic Prostate Cancer
– Identify the relationship between the drugs and use it for target finding, drug repurposing, and precision medicine.
– Devise corrective measures for pipeline projects by understanding Metastatic Prostate Cancer pipeline depth and focus of Indication therapeutics
– Developing strategic initiatives to support your drug development activities.
– Optimize your portfolio and keep you in touch with the rapidly changing pharmaceutical markets, and make the best decisions for your business.
– Develop and design in licensing and out licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope
– Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies
– Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline
– Gaining a Full Picture of the Competitive Landscape for Evidence based Decisions

Table of Contents
– Metastatic Prostate Cancer Overview
– Metastatic Prostate Cancer Pipeline Therapeutics
– Metastatic Prostate Cancer Therapeutics under Development by Companies
– Metastatic Prostate Cancer Late Stage Products (Filed and Phase III)
– Comparative Analysis
– Metastatic Prostate Cancer Mid Clinical Stage Products (Phase II)
– Comparative Analysis
– Metastatic Prostate Cancer Early Clinical Stage Products (Phase I and IND Filed)
– Comparative Analysis
– Metastatic Prostate Cancer Discovery and Pre-Clinical Stage Products
– Comparative Analysis
– Drug Candidate Profiles
– Metastatic Prostate Cancer – Therapeutics Assessment
– Assessment by Monotherapy Products
– Assessment by Combination Products
– Assessment by Route of Administration
– Assessment by Molecule Type
– Metastatic Prostate Cancer – Discontinued Products
– Metastatic Prostate Cancer – Dormant Products
– Companies Involved in Therapeutics Development for Metastatic Prostate Cancer
– Appendix
– Methodology
– Contact Us
– Disclaimer

List of Tables

– Number of Products under Development for Metastatic Prostate Cancer, 2014
– Number of Products under Development by Companies
– Comparative Analysis by Late Clinical Stage Products (Filed and Phase III), 2014
– Comparative Analysis Mid Clinical Stage Products (Phase II), 2014
– Comparative Analysis Early Clinical Stage Products (Phase I and IND Filed), 2014
– Comparative Analysis Discovery and Pre-Clinical Stage Products, 2014
– Drug Candidates Profiles
– Metastatic Prostate Cancer Assessment by Monotherapy Products
– Metastatic Prostate Cancer Assessment by Combination Products
– Metastatic Prostate Cancer Assessment by Route of Administration
– Metastatic Prostate Cancer Assessment by Stage and Route of Administration
– Metastatic Prostate Cancer Assessment by Molecule Type
– Metastatic Prostate Cancer Assessment by Stage and Molecule Type
– Metastatic Prostate Cancer Therapeutics – Discontinued Products
– Metastatic Prostate Cancer Therapeutics – Dormant Products
– Products under Development by Companies, 2014

List of Figures

– Number of Products under Development for Metastatic Prostate Cancer, 2014
– Late Clinical Stage Products (Filed and Phase III), 2014
– Mid Clinical Stage Products (Phase II), 2014
– Early Clinical Stage Products (Phase I and IND Filed), 2014
– Discovery and Pre-Clinical Stage Products, 2014
– Metastatic Prostate Cancer Assessment by Monotherapy Products
– Metastatic Prostate Cancer Assessment by Combination Products
– Metastatic Prostate Cancer Assessment by Route of Administration
– Metastatic Prostate Cancer Assessment by Stage and Route of Administration
– Metastatic Prostate Cancer Assessment by Molecule Type
– Metastatic Prostate Cancer Assessment by Stage and Molecule Type

Report Pricing
Single User License: $1250
Site License:$2500
Global License:$4000

For Sample Pages and Report, please contact us at info@delveinsight.com

DelveInsight’s Marketed and Pipeline Reports Going Viral!

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If a market is growing enormously, you need to understand what’s nourishing it

 

DelveInsight Report

DelveInsight has launched its Reports under two brands Pharm Delve and Pharm Insights.

Pharm Delve reports are known for its extensive detailed information of the Marketed drugs– Global Market, API Market & Manufacturers across the US, Europe and Asia specifically China and India and Phase III Pipeline drugs information. These reports provide whole list of companies interested in your business. It gives you the most up to date information on drug marketed data, patent data, upcoming API with lots of potential in market, interested Generic Drug Companies, Active Pharmaceutical Ingredient (API) Manufacturers to determine which companies and therapies are emerging leaders while understanding the market needs.

Pharm Insights covers the pipeline reports. Mechanism of Action Reports launched has become the most known and on demand amongst the clients. The report has highlighted all the under development drugs falling under the specific MOA with the comparative analysis at various stages and therapeutics assessment by monotherapy and combination products and molecule type drug information. The reports have covered each and every detail of the drugs while chemical information and company profile are considered thoroughly.

Five worth Reason for Spending on these Reports

  1. Track your closest Competitors
  2. Identifying potential customers
  3. Prioritizing new drug intermediates to add to the portfolio
  4. Uncovering opportunities Globally
  5. Organic as well as Inorganic Growth

Who can buy these Reports?

  • Pharma Companies
  • Drug Development Companies
  • Generic Manufacturing Companies
  • API Manufacturers
  • Institutions/Universities

 Where to buy?

You can buy these reports from the resellers given : Report Buyer, Report Linker, ASD Media, VPG Market Research, Market Publishers, Bharat Book Bureau and Report stack

About DelveInsight

DelveInsight is a Business consultant and Knowledge Partner and have extensive experience across the value chain of pharmaceutical industry. We provide cutting-edge market and pipeline analysis and API intelligence to the Pharma and Biotech sector, helping clients to quantify market events and evaluate their impact on the valuation of products, portfolios and companies.

At DelveInsight, we believe what we do matters. We are passionate about our work, inspired by the impact it has on our business and our customers. As a team, we believe in winning as one – collaborating to reach shared goals, and developing through challenging and meaningful experiences. The pharmaceuticals market is in its growth stage and we are uniquely positioned to successfully endeavor the dimensions of the fast growing market by providing clear and forthright business recommendations to help clients evaluate potential paths and make vital decisions at all stages of a product’s lifecycle and across multiple business and therapeutic areas.